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10.1038/ncomms15876 http://scihub22266oqcxt.onion/10.1038/ncomms15876 C5481770!5481770!28621313     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28621313.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2017 ; 8 (ä): ä Nephropedia Template TP {{tp|p=28621313|t=2017. Lkb1 maintains Treg cell lineage identity |pdf=|usr=}}{{28621313}} gab.com Text Lkb1 maintains Treg cell lineage identity JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28621313 #FOAvip Regulatory T (Treg) cells are a distinct T-cell lineage characterized by sustained Foxp3 expression and potent suppressor function, but the upstream dominant factors that preserve Treg lineage-specific features are mostly unknown. Here, we show that Lkb1 maintains Treg cell lineage identity by stabilizing Foxp3 expression and enforcing suppressor function. Upon T-cell receptor (TCR) stimulation Lkb1 protein expression is upregulated in Treg cells but not in conventional T cells. Mice with Treg cell-specific deletion of Lkb1 develop a fatal early-onset autoimmune disease, with no Foxp3 expression in most Treg cells. Lkb1 stabilizes Foxp3 expression by preventing STAT4-mediated methylation of the conserved noncoding sequence 2 (CNS2) in the Foxp3 locus. Independent of maintaining Foxp3 expression, Lkb1 programs the expression of a wide spectrum of immunosuppressive genes, through mechanisms involving the augmentation of TGF-? signalling. These findings identify a critical function of Lkb1 in maintaining Treg cell lineage identity. Twit Text FOAVip Lkb1 maintains Treg cell lineage identity ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28621313 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28621313 #FOAvip English Wikipedia <ref>{{Cite pmid|28621313}}</ref> Lkb1 maintains Treg cell lineage identity #MMPMID28621313 Wu D; Luo Y; Guo W; Niu Q; Xue T; Yang F; Sun X; Chen S; Liu Y; Liu J; Sun Z; Zhao C; Huang H; Liao F; Han Z; Zhou D; Yang Y; Xu G; Cheng T; Feng X Nat Commun 2017[]; 8 (ä): ä PMID28621313show ga Regulatory T (Treg) cells are a distinct T-cell lineage characterized by sustained Foxp3 expression and potent suppressor function, but the upstream dominant factors that preserve Treg lineage-specific features are mostly unknown. Here, we show that Lkb1 maintains Treg cell lineage identity by stabilizing Foxp3 expression and enforcing suppressor function. Upon T-cell receptor (TCR) stimulation Lkb1 protein expression is upregulated in Treg cells but not in conventional T cells. Mice with Treg cell-specific deletion of Lkb1 develop a fatal early-onset autoimmune disease, with no Foxp3 expression in most Treg cells. Lkb1 stabilizes Foxp3 expression by preventing STAT4-mediated methylation of the conserved noncoding sequence 2 (CNS2) in the Foxp3 locus. Independent of maintaining Foxp3 expression, Lkb1 programs the expression of a wide spectrum of immunosuppressive genes, through mechanisms involving the augmentation of TGF-? signalling. These findings identify a critical function of Lkb1 in maintaining Treg cell lineage identity. äLkb1 maintains Treg cell lineage identity (epmc).pdf DeepDyve Pubget Overpricing