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2020 ; 8
(5
): 509-519
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Liver injury in COVID-19: The current evidence
#MMPMID32450787
Alqahtani SA
; Schattenberg JM
United European Gastroenterol J
2020[Jun]; 8
(5
): 509-519
PMID32450787
show ga
Patients with novel coronavirus disease 2019 (COVID-19) experience various
degrees of liver function abnormalities. Liver injury requires extensive work-up
and continuous surveillance and can be multifactorial and heterogeneous in
nature. In the context of COVID-19, clinicians will have to determine whether
liver injury is related to an underlying liver disease, drugs used for the
treatment of COVID-19, direct effect of the virus, or a complicated disease
course. Recent studies proposed several theories on potential mechanisms of liver
injury in these patients. This review summarizes current evidence related to
hepatobiliary complications in COVID-19, provides an overview of the available
case series and critically elucidates the proposed mechanisms and provides
recommendations for clinicians.
|*Betacoronavirus/physiology
[MESH]
|Antiviral Agents/adverse effects/therapeutic use
[MESH]
|COVID-19
[MESH]
|COVID-19 Drug Treatment
[MESH]
|Chemical and Drug Induced Liver Injury/etiology
[MESH]
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