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2015 ; 31
(3
): 194-8
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Liver Transplantation for Patients with Cholestatic Liver Diseases
#MMPMID26468315
Schöning W
; Schmeding M
; Ulmer F
; Andert A
; Neumann U
Viszeralmedizin
2015[Jun]; 31
(3
): 194-8
PMID26468315
show ga
BACKGROUND: Cholestatic liver diseases (CD) account for 11% of all liver
transplantations (LT) in the Eurotransplant region. Despite the excellent
long-term outcome that is considerably superior to all other indications for LT,
transplant surgeons and physicians face nowadays - in the era of MELD (Model of
End-Stage Liver Disease)-based allocation, organ shortage, and extended
allocation policies - more and more challenges in this patient cohort, especially
since there is no curative medical treatment for these entities. METHODS: Based
on a literature review and personal experience in liver transplantation for CD,
we show the status quo of indication, allocation, and outcome as well as
potential strategies to overcome long waiting times and organ shortage. RESULTS:
Concerning graft and patient survival, CD remain the 'best indications' for LT.
Since the implementation of MELD-based allocation results in patients with
primary sclerosing cholangitis (PSC) could be preserved on good levels only by
the implementation and revision of standard exceptions. Recurrence of PSC after
LT remains a challenge for transplant surgeons and physicians. New data has
kindled a debate on biliary reconstruction in LT for PSC. Promising data on
living donor LT motivate to push the boundaries in this direction. CONCLUSION: CD
are excellent indications for liver transplantation since excellent long-term
outcomes are achievable when the transplant is performed at the right time. The
decisions concerning evaluation, listing, and allocation should be made by an
interdisciplinary team of gastroenterologists and transplant surgeons.