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10.1152/ajprenal.00326.2014 http://scihub22266oqcxt.onion/10.1152/ajprenal.00326.2014 C4233281!4233281!25186296     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25186296.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Am+J+Physiol+Renal+Physiol 2014 ; 307 (10): F1162-8 Nephropedia Template TP {{tp|p=25186296|t=2014. Live nephron imaging by MRI |pdf=|usr=}}{{25186296}} gab.com Text Live nephron imaging by MRI JO: Am J Physiol Renal Physiol http://www.kidney.de/pget.php?&tw=1&pmid=25186296 #FOAvip The local sensitivity of MRI can be improved with small MR detectors placed close to regions of interest. However, to maintain such sensitivity advantage, local detectors normally need to communicate with the external amplifier through cable connections, which prevent the use of local detectors as implantable devices. Recently, an integrated wireless amplifier was developed that can efficiently amplify and broadcast locally detected signals, so that the local sensitivity was enhanced without the need for cable connections. This integrated detector enabled the live imaging of individual glomeruli using negative contrast introduced by cationized ferritin, and the live imaging of renal tubules using positive contrast introduced by gadopentetate dimeglumine. Here, we utilized the high blood flow to image individual glomeruli as hyperintense regions without any contrast agent. These hyperintense regions were identified for pixels with signal intensities higher than the local average. Addition of Mn2+ allowed the simultaneous detection of both glomeruli and renal tubules: Mn2+ was primarily reabsorbed by renal tubules, which would be distinguished from glomeruli due to higher enhancement in T1-weighted MRI. Dynamic studies of Mn2+ absorption confirmed the differential absorption affinity of glomeruli and renal tubules, potentially enabling the in vivo observation of nephron function. Twit Text FOAVip Live nephron imaging by MRI ????Am J Physiol Renal Physiol http://www.kidney.de/pget.php?&tw=1&pmid=25186296 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25186296 #FOAvip English Wikipedia <ref>{{Cite pmid|25186296}}</ref> Live nephron imaging by MRI #MMPMID25186296 Qian C; Yu X; Pothayee N; Dodd S; Bouraoud N; Star R; Bennett K; Koretsky A Am J Physiol Renal Physiol 2014[Nov]; 307 (10): F1162-8 PMID25186296show ga The local sensitivity of MRI can be improved with small MR detectors placed close to regions of interest. However, to maintain such sensitivity advantage, local detectors normally need to communicate with the external amplifier through cable connections, which prevent the use of local detectors as implantable devices. Recently, an integrated wireless amplifier was developed that can efficiently amplify and broadcast locally detected signals, so that the local sensitivity was enhanced without the need for cable connections. This integrated detector enabled the live imaging of individual glomeruli using negative contrast introduced by cationized ferritin, and the live imaging of renal tubules using positive contrast introduced by gadopentetate dimeglumine. Here, we utilized the high blood flow to image individual glomeruli as hyperintense regions without any contrast agent. These hyperintense regions were identified for pixels with signal intensities higher than the local average. Addition of Mn2+ allowed the simultaneous detection of both glomeruli and renal tubules: Mn2+ was primarily reabsorbed by renal tubules, which would be distinguished from glomeruli due to higher enhancement in T1-weighted MRI. Dynamic studies of Mn2+ absorption confirmed the differential absorption affinity of glomeruli and renal tubules, potentially enabling the in vivo observation of nephron function. äLive nephron imaging by MRI (epmc).pdf DeepDyve Pubget Overpricing