Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25763014
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25763014
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Braz+J+Microbiol
2014 ; 45
(4
): 1117-29
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Live bacterial vaccine vectors: an overview
#MMPMID25763014
da Silva AJ
; Zangirolami TC
; Novo-Mansur MT
; Giordano Rde C
; Martins EA
Braz J Microbiol
2014[]; 45
(4
): 1117-29
PMID25763014
show ga
Genetically attenuated microorganisms, pathogens, and some commensal bacteria can
be engineered to deliver recombinant heterologous antigens to stimulate the host
immune system, while still offering good levels of safety. A key feature of these
live vectors is their capacity to stimulate mucosal as well as humoral and/or
cellular systemic immunity. This enables the use of different forms of
vaccination to prevent pathogen colonization of mucosal tissues, the front door
for many infectious agents. Furthermore, delivery of DNA vaccines and immune
system stimulatory molecules, such as cytokines, can be achieved using these
special carriers, whose adjuvant properties and, sometimes, invasive capacities
enhance the immune response. More recently, the unique features and versatility
of these vectors have also been exploited to develop anti-cancer vaccines, where
tumor-associated antigens, cytokines, and DNA or RNA molecules are delivered.
Different strategies and genetic tools are constantly being developed, increasing
the antigenic potential of agents delivered by these systems, opening fresh
perspectives for the deployment of vehicles for new purposes. Here we summarize
the main characteristics of the different types of live bacterial vectors and
discuss new applications of these delivery systems in the field of vaccinology.
free
free
free
