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2015 ; 11
(ä): 333-42
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Lipidomics in vascular health: current perspectives
#MMPMID26109865
Kolovou G
; Kolovou V
; Mavrogeni S
Vasc Health Risk Manag
2015[]; 11
(ä): 333-42
PMID26109865
show ga
Identifying the mechanisms that convert a healthy vascular wall to an
atherosclerotic wall is of major importance since the consequences may lead to a
shortened lifespan. Classical risk factors (age, smoking, obesity, diabetes
mellitus, hypertension, and dyslipidemia) may result in the progression of
atherosclerotic lesions by processes including inflammation and lipid
accumulation. Thus, the evaluation of blood lipids and the full lipid complement
produced by cells, organisms, or tissues (lipidomics) is an issue of importance.
In this review, we shall describe the recent progress in vascular health research
using lipidomic advances. We will begin with an overview of vascular wall biology
and lipids, followed by a short analysis of lipidomics. Finally, we shall focus
on the clinical implications of lipidomics and studies that have examined
lipidomic approaches and vascular health.