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2013 ; 5
(10
): a016816
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Lipid sorting and multivesicular endosome biogenesis
#MMPMID24086044
Bissig C
; Gruenberg J
Cold Spring Harb Perspect Biol
2013[Oct]; 5
(10
): a016816
PMID24086044
show ga
Intracellular organelles, including endosomes, show differences not only in
protein but also in lipid composition. It is becoming clear from the work of many
laboratories that the mechanisms necessary to achieve such lipid segregation can
operate at very different levels, including the membrane biophysical properties,
the interactions with other lipids and proteins, and the turnover rates or
distribution of metabolic enzymes. In turn, lipids can directly influence the
organelle membrane properties by changing biophysical parameters and by
recruiting partner effector proteins involved in protein sorting and membrane
dynamics. In this review, we will discuss how lipids are sorted in endosomal
membranes and how they impact on endosome functions.