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2015 ; 25
(10
): 1456-65
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Linking RNA biology to lncRNAs
#MMPMID26430155
Goff LA
; Rinn JL
Genome Res
2015[Oct]; 25
(10
): 1456-65
PMID26430155
show ga
The regulatory potential of RNA has never ceased to amaze: from RNA catalysis, to
RNA-mediated splicing, to RNA-based silencing of an entire chromosome during
dosage compensation. More recently, thousands of long noncoding RNA (lncRNA)
transcripts have been identified, the majority with unknown function. Thus, it is
tempting to think that these lncRNAs represent a cadre of new factors that
function through ribonucleic mechanisms. Some evidence points to several lncRNAs
with tantalizing physiological contributions and thought-provoking molecular
modalities. However, dissecting the RNA biology of lncRNAs has been difficult,
and distinguishing the independent contributions of functional RNAs from
underlying DNA elements, or the local act of transcription, is challenging. Here,
we aim to survey the existing literature and highlight future approaches that
will be needed to link the RNA-based biology and mechanisms of lncRNAs in vitro
and in vivo.
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