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10.1098/rsob.170026 http://scihub22266oqcxt.onion/10.1098/rsob.170026 C5413910!5413910 !28446710     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28446710 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Open+Biol 2017 ; 7 (4 ): ä Nephropedia Template TP {{tp|p=28446710 |t=2017. Linear ubiquitin chains: enzymes, mechanisms and biology |pdf=|usr=}}{{28446710 }} gab.com Text Linear ubiquitin chains: enzymes, mechanisms and biology JO: Open Biol http://www.kidney.de/pget.php?&tw=1&pmid=28446710 #FOAvip Ubiquitination is a versatile post-translational modification that regulates a multitude of cellular processes. Its versatility is based on the ability of ubiquitin to form multiple types of polyubiquitin chains, which are recognized by specific ubiquitin receptors to induce the required cellular response. Linear ubiquitin chains are linked through Met 1 and have been established as important players of inflammatory signalling and apoptotic cell death. These chains are generated by a ubiquitin E3 ligase complex called the linear ubiquitin chain assembly complex (LUBAC) that is thus far the only E3 ligase capable of forming linear ubiquitin chains. The complex consists of three subunits, HOIP, HOIL-1L and SHARPIN, each of which have specific roles in the observed biological functions of LUBAC. Furthermore, LUBAC has been found to be associated with OTULIN and CYLD, deubiquitinases that disassemble linear chains and counterbalance the E3 ligase activity of LUBAC. Gene mutations in HOIP, HOIL-1L and OTULIN are found in human patients who suffer from autoimmune diseases, and HOIL-1L mutations are also found in myopathy patients. In this paper, we discuss the mechanisms of linear ubiquitin chain generation and disassembly by their respective enzymes and review our current understanding of their biological functions and association with human diseases. Twit Text FOAVip Linear ubiquitin chains: enzymes, mechanisms and biology ????Open Biol http://www.kidney.de/pget.php?&tw=1&pmid=28446710 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28446710 #FOAvip English Wikipedia <ref>{{Cite pmid|28446710 }}</ref> Linear ubiquitin chains: enzymes, mechanisms and biology #MMPMID28446710 Rittinger K ; Ikeda F Open Biol 2017[Apr]; 7 (4 ): ä PMID28446710 show ga Ubiquitination is a versatile post-translational modification that regulates a multitude of cellular processes. Its versatility is based on the ability of ubiquitin to form multiple types of polyubiquitin chains, which are recognized by specific ubiquitin receptors to induce the required cellular response. Linear ubiquitin chains are linked through Met 1 and have been established as important players of inflammatory signalling and apoptotic cell death. These chains are generated by a ubiquitin E3 ligase complex called the linear ubiquitin chain assembly complex (LUBAC) that is thus far the only E3 ligase capable of forming linear ubiquitin chains. The complex consists of three subunits, HOIP, HOIL-1L and SHARPIN, each of which have specific roles in the observed biological functions of LUBAC. Furthermore, LUBAC has been found to be associated with OTULIN and CYLD, deubiquitinases that disassemble linear chains and counterbalance the E3 ligase activity of LUBAC. Gene mutations in HOIP, HOIL-1L and OTULIN are found in human patients who suffer from autoimmune diseases, and HOIL-1L mutations are also found in myopathy patients. In this paper, we discuss the mechanisms of linear ubiquitin chain generation and disassembly by their respective enzymes and review our current understanding of their biological functions and association with human diseases. |Animals [MESH] |Autoimmune Diseases/genetics/metabolism/pathology [MESH] |Humans [MESH] |Polymorphism, Genetic [MESH] |Protein Domains [MESH] |Protein Subunits/chemistry/genetics/metabolism [MESH] |Signal Transduction [MESH] |Thermotolerance [MESH] |Tumor Necrosis Factors/metabolism [MESH] |Ubiquitin-Protein Ligases/chemistry/genetics/metabolism [MESH] |Ubiquitin/chemistry/*metabolism [MESH]Linear ubiquitin chains: enzymes, mechanisms and biology (epmc).pdf DeepDyve Pubget Overpricing