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10.3390/ijms160818732

http://scihub22266oqcxt.onion/10.3390/ijms160818732
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C4581268!4581268!26270659
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suck abstract from ncbi


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pmid26270659      Int+J+Mol+Sci 2015 ; 16 (8): 18732-40
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  • LincRNA-p21: Implications in Human Diseases #MMPMID26270659
  • Tang SS; Zheng BY; Xiong XD
  • Int J Mol Sci 2015[Aug]; 16 (8): 18732-40 PMID26270659show ga
  • Long noncoding RNAs (lncRNAs), which lack significant protein-coding capacity, regulate various biological processes through diverse and as yet poorly understood molecular mechanisms. However, a number of studies in the past few years have documented important functions for lncRNAs in human diseases. Among these lncRNAs, lincRNA-p21 has been proposed to be a novel regulator of cell proliferation, apoptosis and DNA damage response, and involved in the initiation and progression of human diseases. In this review, we summarize the current knowledge of lincRNA-p21, mainly focus on the known biological functions and its underlying mechanisms. Moreover, we highlight the growing body of evidences for the importance of lincRNA-p21 in diverse human diseases, which indicate lincRNA-p21 as a potential diagnostic marker and/or a valuable therapeutic target for these diseases.
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