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10.1158/1940-6207.CAPR-15-0343 http://scihub22266oqcxt.onion/10.1158/1940-6207.CAPR-15-0343 C4856031!4856031 !26932841     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26932841 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Cancer+Prev+Res+(Phila) 2016 ; 9 (5 ): 335-8 Nephropedia Template TP {{tp|p=26932841 |t=2016. Limitations of the Driver/Passenger Model in Cancer Prevention |pdf=|usr=}}{{26932841 }} gab.com Text Limitations of the Driver/Passenger Model in Cancer Prevention JO: Cancer Prev Res (Phila) http://www.kidney.de/pget.php?&tw=1&pmid=26932841 #FOAvip Mutations detected in cancers are often divided into "drivers" and "passengers." We suggest that this classification is potentially misleading for purposes of early detection and prevention. Specifically, some mutations are frequent in tumors and thus appear to be drivers, but are poor predictors of cancer; other mutations are individually rare and thus appear to be passengers, but may collectively explain a large proportion of risk. The assumptions bundled into the terms "driver" and "passenger" can lead to misunderstandings of neoplastic progression, with unintended consequences including overdiagnosis, overtreatment, and failure to identify the true sources of risk. We argue that samples from healthy, benign, or neoplastic tissues are critical for evaluating the risk of future cancer posed by mutations in a given gene. Cancer Prev Res; 9(5); 335-8. ©2016 AACR. Twit Text FOAVip Limitations of the Driver/Passenger Model in Cancer Prevention ????Cancer Prev Res (Phila) http://www.kidney.de/pget.php?&tw=1&pmid=26932841 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26932841 #FOAvip English Wikipedia <ref>{{Cite pmid|26932841 }}</ref> Limitations of the Driver/Passenger Model in Cancer Prevention #MMPMID26932841 Kuhner MK ; Kostadinov R ; Reid BJ Cancer Prev Res (Phila) 2016[May]; 9 (5 ): 335-8 PMID26932841 show ga Mutations detected in cancers are often divided into "drivers" and "passengers." We suggest that this classification is potentially misleading for purposes of early detection and prevention. Specifically, some mutations are frequent in tumors and thus appear to be drivers, but are poor predictors of cancer; other mutations are individually rare and thus appear to be passengers, but may collectively explain a large proportion of risk. The assumptions bundled into the terms "driver" and "passenger" can lead to misunderstandings of neoplastic progression, with unintended consequences including overdiagnosis, overtreatment, and failure to identify the true sources of risk. We argue that samples from healthy, benign, or neoplastic tissues are critical for evaluating the risk of future cancer posed by mutations in a given gene. Cancer Prev Res; 9(5); 335-8. ©2016 AACR. |Humans [MESH] |Mutation [MESH]Limitations of the Driver/Passenger Model in Cancer Prevention (epmc).pdf DeepDyve Pubget Overpricing