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10.1016/j.tcb.2015.07.010 http://scihub22266oqcxt.onion/10.1016/j.tcb.2015.07.010 C4628868!4628868 !26437585     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26437585 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Trends+Cell+Biol 2015 ; 25 (11 ): 697-707 Nephropedia Template TP {{tp|p=26437585 |t=2015. Ligand-Independent Mechanisms of Notch Activity |pdf=|usr=}}{{26437585 }} gab.com Text Ligand-Independent Mechanisms of Notch Activity JO: Trends Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=26437585 #FOAvip Interaction between the Notch receptor and Delta-Serrate-Lag2 (DSL) ligands is generally deemed to be the starting point of the Notch signaling cascade, after which, Notch is cleaved and the intracellular domain acts as a transcriptional coactivator. By contrast, Notch protein can become activated independent of ligand stimulus through recently identified endosomal trafficking routes as well as through aberrant regulation of Notch components during Notch trafficking, ubiquitination, and degradation. In this review, we summarize genes implicated in ligand-independent Notch activity and remark on the mechanisms by which this process could occur. Twit Text FOAVip Ligand-Independent Mechanisms of Notch Activity ????Trends Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=26437585 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26437585 #FOAvip English Wikipedia <ref>{{Cite pmid|26437585 }}</ref> Ligand-Independent Mechanisms of Notch Activity #MMPMID26437585 Palmer WH ; Deng WM Trends Cell Biol 2015[Nov]; 25 (11 ): 697-707 PMID26437585 show ga Interaction between the Notch receptor and Delta-Serrate-Lag2 (DSL) ligands is generally deemed to be the starting point of the Notch signaling cascade, after which, Notch is cleaved and the intracellular domain acts as a transcriptional coactivator. By contrast, Notch protein can become activated independent of ligand stimulus through recently identified endosomal trafficking routes as well as through aberrant regulation of Notch components during Notch trafficking, ubiquitination, and degradation. In this review, we summarize genes implicated in ligand-independent Notch activity and remark on the mechanisms by which this process could occur. |Animals [MESH] |Endosomes/genetics/*metabolism [MESH] |Humans [MESH] |Ligands [MESH] |Protein Binding/physiology [MESH] |Receptors, Notch/genetics/*metabolism [MESH]Ligand-Independent Mechanisms of Notch Activity (epmc).pdf DeepDyve Pubget Overpricing