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Neurol Clin
2017[May]; 35
(2
): 325-338
PMID28410662
show ga
Dementia syndromes associated with Lewy bodies are subdivided into dementia with
Lewy bodies (DLB), an underdiagnosed cause of dementia in the elderly, and
Parkinson disease with dementia (PDD), cognitive impairment appearing in people
diagnosed with Parkinson disease. Their neuropathologic substrates are the
widespread distribution of aggregates of the protein ?-synuclein in neurons in
cortical brain regions, accompanied by variable Alzheimer pathology. Clinical
features of DLB and PDD include distinctive changes in cognition, behavior,
movement, sleep, and autonomic function. Diagnostic criteria for DLB and PDD
incorporate these features. Current treatment options for DLB and PDD are
symptomatic.
|*Disease Management
[MESH]
|*Lewy Body Disease/pathology/physiopathology/therapy
[MESH]
free
free
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