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2017 ; 9
(6
): 487-497
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Leveraging natural killer cells for cancer immunotherapy
#MMPMID28472904
Grossenbacher SK
; Aguilar EG
; Murphy WJ
Immunotherapy
2017[May]; 9
(6
): 487-497
PMID28472904
show ga
Natural killer (NK) cells are potent antitumor effector cells of the innate
immune system. Based on their ability to eradicate tumors in vitro and in animal
models, significant enthusiasm surrounds the prospect of leveraging human NK
cells as vehicles for cancer immunotherapy. While interest in manipulating the
effector functions of NK cells has existed for over 30 years, there is renewed
optimism for this approach today. Although T cells receive much of the clinical
and preclinical attention when it comes to cancer immunotherapy, new strategies
are utilizing adoptive NK-cell immunotherapy and monoclonal antibodies and
engineered molecules which have been developed to specifically activate NK cells
against tumors. Despite the numerous challenges associated with the preclinical
and clinical development of NK cell-based therapies for cancer, NK cells possess
many unique immunological properties and hold the potential to provide an
effective means for cancer immunotherapy.