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2018 ; 83
(ä): e76-e81
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Leukoaraiosis - new concepts and modern imaging
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Marek M
; Horyniecki M
; Fr?czek M
; Kluczewska E
Pol J Radiol
2018[]; 83
(ä): e76-e81
PMID30038682
show ga
Leukoaraiosis is a pathological appearance of the brain white matter, which has
long been believed to be caused by perfusion disturbances within the arterioles
perforating through the deep brain structures. Due to its complex
etiopathogenesis and clinical relevance, leukoaroisosis has been investigated in
a multitude of studies. As regards the clinical implications of leukoaraiosis,
this neuroimaging finding is strongly related to ischaemic stroke, unfavourable
course of ischaemic stroke in the acute phase, worse long-term outcomes, and
cognitive disturbances. The morphological changes in the deep white matter that
are collectively described as leukoaraiosis, despite a seemingly homogenous
appearance, probably resulting from various causes, such as atherosclerosis,
neurotoxic factors including radiation therapy and chemotherapy, and
neuroinfections. Based on our experience and recent literature, we present the
symptomatology of leukoaroisosis and similar radiological abnormalities of the
cerebral white matter.