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10.1097/COH.0000000000000362 http://scihub22266oqcxt.onion/10.1097/COH.0000000000000362 C5389590!5389590 !28230655     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28230655 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28230655 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Curr+Opin+HIV+AIDS 2017 ; 12 (3 ): 216-221 Nephropedia Template TP {{tp|p=28230655 |t=2017. Lessons learned from human HIV vaccine trials |pdf=|usr=}}{{28230655 }} gab.com Text Lessons learned from human HIV vaccine trials JO: Curr Opin HIV AIDS http://www.kidney.de/pget.php?&tw=1&pmid=28230655 #FOAvip PURPOSE OF REVIEW: The ability to induce broadly neutralizing antibody (bNAb) responses is likely essential for development of a globally effective HIV vaccine. Unfortunately, human vaccine trials conducted to date have failed to elicit broad plasma neutralization of primary virus isolates. Despite this limitation, in-depth analysis of the vaccine-induced memory B-cell repertoire can provide valuable insights into the presence and function of subdominant B-cell responses, and identify initiation of antibody lineages that may be on a path towards development of neutralization breadth. RECENT FINDINGS: Characterization of the functional capabilities of monoclonal antibodies isolated from a HIV-1 vaccine trial with modest efficacy has revealed mechanisms by which non-neutralizing antibodies are presumed to have mediated protection. In addition, B-cell repertoire analysis has demonstrated that vaccine boosts shifted the HIV-specific B-cell repertoire, expanding pools of cells with long third heavy chain complementarity determining regions - a characteristic of some bNAb lineages. SUMMARY: Detailed analysis of memory B-cell repertoires and evaluating the effector functions of isolated monoclonal antibodies expands what we can learn from human vaccine trails, and may provide knowledge that can enable rational design of novel approaches to drive maturation of subdominant disfavored bNAb lineages. Twit Text FOAVip Lessons learned from human HIV vaccine trials ????Curr Opin HIV AIDS http://www.kidney.de/pget.php?&tw=1&pmid=28230655 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28230655 #FOAvip English Wikipedia <ref>{{Cite pmid|28230655 }}</ref> Lessons learned from human HIV vaccine trials #MMPMID28230655 Pollara J ; Easterhoff D ; Fouda GG Curr Opin HIV AIDS 2017[May]; 12 (3 ): 216-221 PMID28230655 show ga PURPOSE OF REVIEW: The ability to induce broadly neutralizing antibody (bNAb) responses is likely essential for development of a globally effective HIV vaccine. Unfortunately, human vaccine trials conducted to date have failed to elicit broad plasma neutralization of primary virus isolates. Despite this limitation, in-depth analysis of the vaccine-induced memory B-cell repertoire can provide valuable insights into the presence and function of subdominant B-cell responses, and identify initiation of antibody lineages that may be on a path towards development of neutralization breadth. RECENT FINDINGS: Characterization of the functional capabilities of monoclonal antibodies isolated from a HIV-1 vaccine trial with modest efficacy has revealed mechanisms by which non-neutralizing antibodies are presumed to have mediated protection. In addition, B-cell repertoire analysis has demonstrated that vaccine boosts shifted the HIV-specific B-cell repertoire, expanding pools of cells with long third heavy chain complementarity determining regions - a characteristic of some bNAb lineages. SUMMARY: Detailed analysis of memory B-cell repertoires and evaluating the effector functions of isolated monoclonal antibodies expands what we can learn from human vaccine trails, and may provide knowledge that can enable rational design of novel approaches to drive maturation of subdominant disfavored bNAb lineages. |AIDS Vaccines/*administration & dosage/immunology [MESH] |Animals [MESH] |Antibodies, Neutralizing/immunology [MESH] |B-Lymphocytes/immunology [MESH] |Clinical Trials as Topic [MESH] |HIV Antibodies/*immunology [MESH] |HIV Infections/*immunology/prevention & control/virology [MESH] |HIV-1/genetics/*immunology/physiology [MESH]Lessons learned from human HIV vaccine trials (epmc).pdf DeepDyve Pubget Overpricing