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2013 ; 3
(12
): a015495
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Lessons and limits of mouse models
#MMPMID24296351
Chong AS
; Alegre ML
; Miller ML
; Fairchild RL
Cold Spring Harb Perspect Med
2013[Dec]; 3
(12
): a015495
PMID24296351
show ga
Seminal studies in rabbits and rodent transplantation models by Peter Medawar
revealed that cellular processes, rather than humoral antibodies, are central to
the acute rejection of transplanted organs, and much of basic transplantation
research continues to be focused on the biology and control of these cells, which
were subsequently shown to be T cells. However, the success of current
immunosuppression at controlling T-cell-mediated rejection has resulted in an
increasing awareness of antibody-mediated rejection in the clinic. This, in turn,
has fueled an emerging interest in the biology of allospecific antibodies, the B
cells that produce these antibodies, and the development of mouse models that
allow their investigation. Here we summarize some of the more widely used mouse
models that have been developed to study the immunobiology of alloreactivity,
transplantation rejection and tolerance, and used to identify therapeutic
strategies that modulate these events.
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