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2016 ; 11
(5
): 2959-2964
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Lauren classification and individualized chemotherapy in gastric cancer
#MMPMID27123046
Ma J
; Shen H
; Kapesa L
; Zeng S
Oncol Lett
2016[May]; 11
(5
): 2959-2964
PMID27123046
show ga
Gastric cancer is one of the most common malignancies worldwide. During the last
50 years, the histological classification of gastric carcinoma has been largely
based on Lauren's criteria, in which gastric cancer is classified into two major
histological subtypes, namely intestinal type and diffuse type adenocarcinoma.
This classification was introduced in 1965, and remains currently widely accepted
and employed, since it constitutes a simple and robust classification approach.
The two histological subtypes of gastric cancer proposed by the Lauren
classification exhibit a number of distinct clinical and molecular
characteristics, including histogenesis, cell differentiation, epidemiology,
etiology, carcinogenesis, biological behaviors and prognosis. Gastric cancer
exhibits varied sensitivity to chemotherapy drugs and significant heterogeneity;
therefore, the disease may be a target for individualized therapy. The Lauren
classification may provide the basis for individualized treatment for advanced
gastric cancer, which is increasingly gaining attention in the scientific field.
However, few studies have investigated individualized treatment that is guided by
pathological classification. The aim of the current review is to analyze the two
major histological subtypes of gastric cancer, as proposed by the Lauren
classification, and to discuss the implications of this for personalized
chemotherapy.