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10.14670/HH-11-622 http://scihub22266oqcxt.onion/10.14670/HH-11-622 C4665617!4665617 !25892148     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25892148 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Histol+Histopathol 2015 ; 30 (11 ): 1255-69 Nephropedia Template TP {{tp|p=25892148 |t=2015. Laser capture microdissection: Big data from small samples |pdf=|usr=}}{{25892148 }} gab.com Text Laser capture microdissection: Big data from small samples JO: Histol Histopathol http://www.kidney.de/pget.php?&tw=1&pmid=25892148 #FOAvip Any tissue is made up of a heterogeneous mix of spatially distributed cell types. In response to any (patho) physiological cue, responses of each cell type in any given tissue may be unique and cannot be homogenized across cell-types and spatial co-ordinates. For example, in response to myocardial infarction, on one hand myocytes and fibroblasts of the heart tissue respond differently. On the other hand, myocytes in the infarct core respond differently compared to those in the peri-infarct zone. Therefore, isolation of pure targeted cells is an important and essential step for the molecular analysis of cells involved in the progression of disease. Laser capture microdissection (LCM) is powerful to obtain a pure targeted cell subgroup, or even a single cell, quickly and precisely under the microscope, successfully tackling the problem of tissue heterogeneity in molecular analysis. This review presents an overview of LCM technology, the principles, advantages and limitations and its down-stream applications in the fields of proteomics, genomics and transcriptomics. With powerful technologies and appropriate applications, this technique provides unprecedented insights into cell biology from cells grown in their natural tissue habitat as opposed to those cultured in artificial petri dish conditions. Twit Text FOAVip Laser capture microdissection: Big data from small samples ????Histol Histopathol http://www.kidney.de/pget.php?&tw=1&pmid=25892148 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25892148 #FOAvip English Wikipedia <ref>{{Cite pmid|25892148 }}</ref> Laser capture microdissection: Big data from small samples #MMPMID25892148 Datta S ; Malhotra L ; Dickerson R ; Chaffee S ; Sen CK ; Roy S Histol Histopathol 2015[Nov]; 30 (11 ): 1255-69 PMID25892148 show ga Any tissue is made up of a heterogeneous mix of spatially distributed cell types. In response to any (patho) physiological cue, responses of each cell type in any given tissue may be unique and cannot be homogenized across cell-types and spatial co-ordinates. For example, in response to myocardial infarction, on one hand myocytes and fibroblasts of the heart tissue respond differently. On the other hand, myocytes in the infarct core respond differently compared to those in the peri-infarct zone. Therefore, isolation of pure targeted cells is an important and essential step for the molecular analysis of cells involved in the progression of disease. Laser capture microdissection (LCM) is powerful to obtain a pure targeted cell subgroup, or even a single cell, quickly and precisely under the microscope, successfully tackling the problem of tissue heterogeneity in molecular analysis. This review presents an overview of LCM technology, the principles, advantages and limitations and its down-stream applications in the fields of proteomics, genomics and transcriptomics. With powerful technologies and appropriate applications, this technique provides unprecedented insights into cell biology from cells grown in their natural tissue habitat as opposed to those cultured in artificial petri dish conditions. |*Cell Separation/methods [MESH] |*Gene Expression Profiling/methods [MESH] |*Genomics/methods [MESH] |*Laser Capture Microdissection/methods [MESH] |Animals [MESH] |Biomarkers/analysis [MESH] |Genetic Markers [MESH] |Humans [MESH]Laser capture microdissection: Big data from small samples (epmc).pdf DeepDyve Pubget Overpricing