Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29880747
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29880747
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Viruses
2018 ; 10
(6
): ä Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Landscape Phage: Evolution from Phage Display to Nanobiotechnology
#MMPMID29880747
Petrenko VA
Viruses
2018[Jun]; 10
(6
): ä PMID29880747
show ga
The development of phage engineering technology has led to the construction of a
novel type of phage display library-a collection of nanofiber materials with
diverse molecular landscapes accommodated on the surface of phage particles.
These new nanomaterials, called the "landscape phage", serve as a huge resource
of diagnostic/detection probes and versatile construction materials for the
preparation of phage-functionalized biosensors and phage-targeted nanomedicines.
Landscape-phage-derived probes interact with biological threat agents and
generate detectable signals as a part of robust and inexpensive molecular
recognition interfaces introduced in mobile detection devices. The use of
landscape-phage-based interfaces may greatly improve the sensitivity,
selectivity, robustness, and longevity of these devices. In another area of
bioengineering, landscape-phage technology has facilitated the development and
testing of targeted nanomedicines. The development of high-throughput phage
selection methods resulted in the discovery of a variety of cancer
cell-associated phages and phage proteins demonstrating natural proficiency to
self-assemble into various drug- and gene-targeting nanovehicles. The application
of this new "phage-programmed-nanomedicines" concept led to the development of a
number of cancer cell-targeting nanomedicine platforms, which demonstrated
anticancer efficacy in both in vitro and in vivo experiments. This review was
prepared to attract the attention of chemical scientists and bioengineers seeking
to develop functionalized nanomaterials and use them in different areas of
bioscience, medicine, and engineering.