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2015 ; 88
(5
): 999-1013
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Lamination Speeds the Functional Development of Visual Circuits
#MMPMID26607001
Nikolaou N
; Meyer MP
Neuron
2015[Dec]; 88
(5
): 999-1013
PMID26607001
show ga
A common feature of the brain is the arrangement of synapses in layers. To
examine the significance of this organizational feature, we studied the
functional development of direction-selective (DS) circuits in the tectum of
astray mutant zebrafish in which lamination of retinal ganglion cell (RGC) axons
is lost. We show that although never laminar, the tuning of DS-RGC axons
targeting the mutant tectum is normal. Analysis of mutant tectal neurons at late
developmental stages reveals that directional tuning is indistinguishable from
wild-type larvae. Furthermore, we show that structural plasticity of tectal
dendrites and RGC axons compensates for the loss of lamination, establishing
connectivity between DS-RGCs and their normal tectal targets. However, tectal
direction selectivity is severely perturbed at earlier developmental stages.
Thus, the formation of synaptic laminae is ultimately dispensable for the correct
wiring of direction-selective tectal circuits, but it is crucial for the rapid
assembly of these networks.