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Laboratory evaluation in rheumatic diseases
#MMPMID28396844
Birtane M
; Yavuz S
; Ta?tekin N
World J Methodol
2017[Mar]; 7
(1
): 1-8
PMID28396844
show ga
Autoantibodies can help clinicians to allow early detection of autoimmune
diseases and their clinical manifestations, to determine effective monitoring of
prognosis and the treatment response. From this point, they have a high impact in
rheumatic disease management. When used carefully they allow rapid diagnosis and
appropriate treatment. However, as they may be present in healthy population they
may cause confusion for interpreting the situation. False positive test results
may lead to wrong treatment and unnecessary anxiety for patients. Autoantibody
positivity alone does not make a diagnosis. Similarly, the absence of
autoantibodies alone does not exclude diagnosis. The success of the test is
closely related to sensitivity, specificity and likelihood ratios. So,
interpretation of these is very important for a proper laboratory evaluation. In
conclusion, in spite of the remarkable advances in science and technology, a
deeply investigated anamnesis and comprehensive physical examination still
continue to be the best diagnostic method. The most correct approach is that
clinicians apply laboratory tests to confirm or exclude preliminary diagnosis
based on anamnesis and physical examination. This review will discuss these
issues.
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