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10.1016/j.leukres.2015.03.010 http://scihub22266oqcxt.onion/10.1016/j.leukres.2015.03.010 C4553223!4553223 !25850729     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25850729 &cmd=llinks): Failed to open stream: HTTP request failed! 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LFA-1-targeting Leukotoxin (LtxA; Leukothera®) causes lymphoma tumor regression in a humanized mouse model and requires caspase-8 and Fas to kill malignant lymphocytes |pdf=|usr=}}{{25850729 }} gab.com Text LFA-1-targeting Leukotoxin (LtxA; Leukothera®) causes lymphoma tumor regression in a humanized mouse model and requires caspase-8 and Fas to kill malignant lymphocytes JO: Leuk Res http://www.kidney.de/pget.php?&tw=1&pmid=25850729 #FOAvip Leukotoxin (LtxA) is a protein secreted from the oral bacterium Aggregatibacter actinomycetemcomitans. LtxA binds to the ?2 integrin lymphocyte-associated function antigen-1 (LFA-1) on human white blood cells (WBCs), resulting in cell death. LtxA is currently under investigation as a novel therapy (Leukothera(®)) for treating hematologic malignancies and autoimmune diseases. We show here that LtxA has potent in vivo anti-lymphoma activity in mice. LtxA caused complete regression of B-cell tumors and promoted long-term survival of mice. The mechanism of LtxA-mediated killing of malignant lymphocytes was further examined. We found that LtxA kills malignant lymphocytes by a novel mechanism requiring the death receptor Fas and caspase-8, but not Fas ligand (FasL) or caspase-9. We also determined that LFA-1 and Fas are closely associated on the cell surface and this proximity of LFA-1 and Fas could explain how signaling through an integrin can lead to cell death. In addition to LFA-1, this work reveals a second surface protein, Fas, that is critical for LtxA-mediated cell death. Knowledge of the mechanism of cell death induced by LtxA will facilitate the development and understanding of this potent experimental therapeutic agent. Twit Text FOAVip LFA-1-targeting Leukotoxin (LtxA; Leukothera®) causes lymphoma tumor regression in a humanized mouse model and requires caspase-8 and Fas to kill malignant lymphocytes ????Leuk Res http://www.kidney.de/pget.php?&tw=1&pmid=25850729 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25850729 #FOAvip English Wikipedia <ref>{{Cite pmid|25850729 }}</ref> LFA-1-targeting Leukotoxin (LtxA; Leukothera®) causes lymphoma tumor regression in a humanized mouse model and requires caspase-8 and Fas to kill malignant lymphocytes #MMPMID25850729 DiFranco KM ; Johnson-Farley N ; Bertino JR ; Elson D ; Vega BA ; Belinka BA Jr ; Kachlany SC Leuk Res 2015[Jun]; 39 (6 ): 649-56 PMID25850729 show ga Leukotoxin (LtxA) is a protein secreted from the oral bacterium Aggregatibacter actinomycetemcomitans. LtxA binds to the ?2 integrin lymphocyte-associated function antigen-1 (LFA-1) on human white blood cells (WBCs), resulting in cell death. LtxA is currently under investigation as a novel therapy (Leukothera(®)) for treating hematologic malignancies and autoimmune diseases. We show here that LtxA has potent in vivo anti-lymphoma activity in mice. LtxA caused complete regression of B-cell tumors and promoted long-term survival of mice. The mechanism of LtxA-mediated killing of malignant lymphocytes was further examined. We found that LtxA kills malignant lymphocytes by a novel mechanism requiring the death receptor Fas and caspase-8, but not Fas ligand (FasL) or caspase-9. We also determined that LFA-1 and Fas are closely associated on the cell surface and this proximity of LFA-1 and Fas could explain how signaling through an integrin can lead to cell death. In addition to LFA-1, this work reveals a second surface protein, Fas, that is critical for LtxA-mediated cell death. Knowledge of the mechanism of cell death induced by LtxA will facilitate the development and understanding of this potent experimental therapeutic agent. |*Lymphoma, B-Cell/drug therapy/metabolism/pathology [MESH] |Aggregatibacter actinomycetemcomitans/chemistry [MESH] |Animals [MESH] |B-Lymphocytes/metabolism [MESH] |Bacterial Toxins/chemistry/*pharmacology [MESH] |Caspase 8/*metabolism [MESH] |Caspase 9/metabolism [MESH] |Drug Delivery Systems [MESH] |Exotoxins/chemistry/*pharmacology [MESH] |Humans [MESH] |Immunosuppressive Agents/chemistry/*pharmacology [MESH] |Jurkat Cells [MESH] |Lymphocyte Function-Associated Antigen-1 [MESH] |Mice [MESH] |Mice, Inbred NOD [MESH] |Mice, SCID [MESH] |Xenograft Model Antitumor Assays [MESH]LFA-1-targeting Leukotoxin (LtxA; Leukothera®) causes lymphoma tumor r(epmc).pdf DeepDyve Pubget Overpricing