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2018 ; 9
(ä): 952
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LFA-1 in T Cell Migration and Differentiation
#MMPMID29774029
Walling BL
; Kim M
Front Immunol
2018[]; 9
(ä): 952
PMID29774029
show ga
Maintenance of homeostatic immune surveillance and development of effective
adaptive immune responses require precise regulation of spatial and temporal
lymphocyte trafficking throughout the body to ensure pathogen clearance and
memory generation. Dysregulation of lymphocyte activation and migration can lead
to impaired adaptive immunity, recurrent infections, and an array of autoimmune
diseases and chronic inflammation. Central to the recruitment of T cells,
integrins are cell surface receptors that regulate adhesion, signal transduction,
and migration. With 24 integrin pairs having been discovered to date, integrins
are defined not only by the composition of the heterodimeric pair but by
cell-type specific expression and their ligands. Furthermore, integrins not only
facilitate adhesion but also induce intracellular signaling and have recently
been uncovered as mechanosensors providing additional complexity to the signaling
pathways. Among several leukocyte-specific integrins, lymphocyte
function-associated antigen-1 (LFA-1 or ?(L)?(2); CD11a/CD18) is a key T cell
integrin, which plays a major role in regulating T cell activation and migration.
Adhesion to LFA-1's ligand, intracellular adhesion receptor 1 (ICAM-1)
facilitates firm endothelium adhesion, prolonged contact with antigen-presenting
cells, and binding to target cells for killing. While the downstream signaling
pathways utilized by LFA-1 are vastly conserved they allow for highly disparate
responses. Here, we summarize the roles of LFA-1 and ongoing studies to better
understand its functions and regulation.
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