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10.3892/mmr.2017.6180 http://scihub22266oqcxt.onion/10.3892/mmr.2017.6180 C5364969!5364969 !28259899     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28259899 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28259899 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Med+Rep 2017 ; 15 (4 ): 1654-1660 Nephropedia Template TP {{tp|p=28259899 |t=2017. LATS1 suppresses proliferation and invasion of cervical cancer |pdf=|usr=}}{{28259899 }} gab.com Text LATS1 suppresses proliferation and invasion of cervical cancer JO: Mol Med Rep http://www.kidney.de/pget.php?&tw=1&pmid=28259899 #FOAvip Loss of large tumor suppressor kinase 1 (LATS1)Y has been implicated in numerous types of human cancer. However, its involvement in human cervical cancer remains to be elucidated. The present study aimed to investigate the clinical significance and biological characteristics of LATS1 in human cervical cancer. The present study investigated the protein expression levels of LATS1 in tissues from 80 cases of cervical cancer using immunohistochemistry and demonstrated that LATS1 was downregulated in 45% (36/80) of cervical cancers. Transfection of LATS1 was performed in the SiHa cell line and LATS1 siRNA knockdown was performed in the Caski cell line. MTT assay and Matrigel invasion assay indicated that LATS1 overexpression inhibited cell proliferation and invasion. LATS1 overexpression upregulated p27 expression, and downregulated the expression of cyclin E and matrix metalloproteinase 9. In addition, LATS1 overexpression stimulated yes?associated protein 1 (YAP) phosphorylation. Depletion of LATS1 in Caski cells resulted in the opposite effects. The current study demonstrated that LATS1 was downregulated in cervical cancer and may suppress cell growth and invasion through regulating the expression of cyclin E, p27, MMP9 and YAP. Twit Text FOAVip LATS1 suppresses proliferation and invasion of cervical cancer ????Mol Med Rep http://www.kidney.de/pget.php?&tw=1&pmid=28259899 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28259899 #FOAvip English Wikipedia <ref>{{Cite pmid|28259899 }}</ref> LATS1 suppresses proliferation and invasion of cervical cancer #MMPMID28259899 Deng J ; Zhang W ; Liu S ; An H ; Tan L ; Ma L Mol Med Rep 2017[Apr]; 15 (4 ): 1654-1660 PMID28259899 show ga Loss of large tumor suppressor kinase 1 (LATS1)Y has been implicated in numerous types of human cancer. However, its involvement in human cervical cancer remains to be elucidated. The present study aimed to investigate the clinical significance and biological characteristics of LATS1 in human cervical cancer. The present study investigated the protein expression levels of LATS1 in tissues from 80 cases of cervical cancer using immunohistochemistry and demonstrated that LATS1 was downregulated in 45% (36/80) of cervical cancers. Transfection of LATS1 was performed in the SiHa cell line and LATS1 siRNA knockdown was performed in the Caski cell line. MTT assay and Matrigel invasion assay indicated that LATS1 overexpression inhibited cell proliferation and invasion. LATS1 overexpression upregulated p27 expression, and downregulated the expression of cyclin E and matrix metalloproteinase 9. In addition, LATS1 overexpression stimulated yes?associated protein 1 (YAP) phosphorylation. Depletion of LATS1 in Caski cells resulted in the opposite effects. The current study demonstrated that LATS1 was downregulated in cervical cancer and may suppress cell growth and invasion through regulating the expression of cyclin E, p27, MMP9 and YAP. |Adaptor Proteins, Signal Transducing/metabolism [MESH] |Adult [MESH] |Aged [MESH] |Cell Line, Tumor [MESH] |Cell Proliferation [MESH] |Cyclin E/metabolism [MESH] |Cyclin-Dependent Kinase Inhibitor p27/metabolism [MESH] |Female [MESH] |Humans [MESH] |Matrix Metalloproteinase 9/metabolism [MESH] |Middle Aged [MESH] |Neoplasm Invasiveness [MESH] |Phosphoproteins/metabolism [MESH] |Protein Serine-Threonine Kinases/*metabolism [MESH] |Transcription Factors [MESH] |Transfection [MESH] |Uterine Cervical Neoplasms/*metabolism/*pathology [MESH]LATS1 suppresses proliferation and invasion of cervical cancer (epmc).pdf DeepDyve Pubget Overpricing