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10.2353/ajpath.2006.050875 http://scihub22266oqcxt.onion/10.2353/ajpath.2006.050875 C1606556!1606556 !16565492     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=16565492 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\16565492 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Am+J+Pathol 2006 ; 168 (4 ): 1169-78; quiz 1404-5 Nephropedia Template TP {{tp|p=16565492 |t=2006. Kupffer cell-dependent hepatitis occurs during influenza infection |pdf=|usr=}}{{16565492 }} gab.com Text Kupffer cell-dependent hepatitis occurs during influenza infection JO: Am J Pathol http://www.kidney.de/pget.php?&tw=1&pmid=16565492 #FOAvip Respiratory infections, including influenza in humans, are often accompanied by a hepatitis that is usually mild and self-limiting. The mechanism of this kind of liver damage is not well understood. In the present study, we show that influenza-associated hepatitis occurs due to the formation of inflammatory foci that include apoptotic hepatocytes, antigen-specific CD8(+) T cells, and Kupffer cells. Serum aminotransaminase levels were elevated, and both the histological and serum enzyme markers of hepatitis were increased in secondary influenza infection, consistent with a primary role for antigen-specific T cells in the pathogenesis. No virus could be detected in the liver, making this a pure example of "collateral damage" of the liver. Notably, removal of the Kupffer cells prevented the hepatitis. Such hepatic collateral damage may be a general consequence of expanding CD8(+) T-cell populations during many extrahepatic viral infections, yielding important implications for liver pathobiology. Twit Text FOAVip Kupffer cell-dependent hepatitis occurs during influenza infection ????Am J Pathol http://www.kidney.de/pget.php?&tw=1&pmid=16565492 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=16565492 #FOAvip English Wikipedia <ref>{{Cite pmid|16565492 }}</ref> Kupffer cell-dependent hepatitis occurs during influenza infection #MMPMID16565492 Polakos NK ; Cornejo JC ; Murray DA ; Wright KO ; Treanor JJ ; Crispe IN ; Topham DJ ; Pierce RH Am J Pathol 2006[Apr]; 168 (4 ): 1169-78; quiz 1404-5 PMID16565492 show ga Respiratory infections, including influenza in humans, are often accompanied by a hepatitis that is usually mild and self-limiting. The mechanism of this kind of liver damage is not well understood. In the present study, we show that influenza-associated hepatitis occurs due to the formation of inflammatory foci that include apoptotic hepatocytes, antigen-specific CD8(+) T cells, and Kupffer cells. Serum aminotransaminase levels were elevated, and both the histological and serum enzyme markers of hepatitis were increased in secondary influenza infection, consistent with a primary role for antigen-specific T cells in the pathogenesis. No virus could be detected in the liver, making this a pure example of "collateral damage" of the liver. Notably, removal of the Kupffer cells prevented the hepatitis. Such hepatic collateral damage may be a general consequence of expanding CD8(+) T-cell populations during many extrahepatic viral infections, yielding important implications for liver pathobiology. |Adolescent [MESH] |Adult [MESH] |Alanine Transaminase/blood [MESH] |Animals [MESH] |CD8-Positive T-Lymphocytes/immunology [MESH] |Hepatitis/*etiology/pathology/virology [MESH] |Hepatocytes/immunology/pathology/virology [MESH] |Humans [MESH] |Influenza A Virus, H1N1 Subtype [MESH] |Influenza, Human/*complications/immunology [MESH] |Killer Cells, Natural/immunology/pathology [MESH] |Kupffer Cells/*immunology/pathology [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Transgenic [MESH]Kupffer cell-dependent hepatitis occurs during influenza infection (epmc).pdf DeepDyve Pubget Overpricing