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2012 ; 14
(7
): 643-7
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Knowledge integration at the center of genomic medicine
#MMPMID22555656
Khoury MJ
; Gwinn M
; Dotson WD
; Schully SD
Genet Med
2012[Jul]; 14
(7
): 643-7
PMID22555656
show ga
Three articles in this issue of Genetics in Medicine describe examples of
"knowledge integration," involving methods for generating and synthesizing
rapidly emerging information on health-related genomic technologies and engaging
stakeholders around the evidence. Knowledge integration, the central process in
translating genomic research, involves three closely related, iterative
components: knowledge management, knowledge synthesis, and knowledge translation.
Knowledge management is the ongoing process of obtaining, organizing, and
displaying evolving evidence. For example, horizon scanning and "infoveillance"
use emerging technologies to scan databases, registries, publications, and
cyberspace for information on genomic applications. Knowledge synthesis is the
process of conducting systematic reviews using a priori rules of evidence. For
example, methods including meta-analysis, decision analysis, and modeling can be
used to combine information from basic, clinical, and population research.
Knowledge translation refers to stakeholder engagement and brokering to influence
policy, guidelines and recommendations, as well as the research agenda to close
knowledge gaps. The ultrarapid production of information requires adequate public
and private resources for knowledge integration to support the evidence-based
development of genomic medicine.