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2015 ; 6
(4
): 351-7
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Klotho in cardiovascular disease: Current and future perspectives
#MMPMID26629318
Donate-Correa J
; Martín-Núñez E
; Mora-Fernández C
; Muros-de-Fuentes M
; Pérez-Delgado N
; Navarro-González JF
World J Biol Chem
2015[Nov]; 6
(4
): 351-7
PMID26629318
show ga
Protein Klotho, beyond its role as a regulator of the phosphatemia, is also
involved in the maintaining of the cardiovascular health, being associated its
alterations with the development of cardiovascular damage and increased
morbi-mortality. For all this, nowadays Klotho is the subject of a thorough
research which is focused on uncover its intimate mechanisms of action, and in
analyzing the utility of its modulation as a potential strategy with clinical
applicability. Molecular mechanisms of Klotho are not well understood but an
emerging research area links Klotho deficiency with vascular pathology. Changes
in this protein have been associated with cardiovascular-related complications
like inflammation, vascular calcification, and endothelial dysfunction. All this
is particularly relevant if considering the recent discovery of Klotho expression
in vascular tissue.