Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.4161/cbt.29482 http://scihub22266oqcxt.onion/10.4161/cbt.29482 C4128853!4128853!24919121     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24919121.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cancer+Biol+Ther 2014 ; 15 (9): 1113-6 Nephropedia Template TP {{tp|p=24919121|t=2014. Kindler syndrome in mice and men |pdf=|usr=}}{{24919121}} gab.com Text Kindler syndrome in mice and men JO: Cancer Biol Ther http://www.kidney.de/pget.php?&tw=1&pmid=24919121 #FOAvip Kindler syndrome (KS) in humans is a severe skin blistering disease associated with inflammation and increased risk of epidermal squamous cell carcinoma (SCC). This disease is known to be caused by loss-of-function mutations in Kindlin-1, a focal adhesion ?-integrin binding protein. Thus far, it has been unclear what specific signaling events occur in KS keratinocytes to promote tumorigenesis, especially since loss of ?-integrins and focal adhesion complexes has been previously shown to prevent or delay tumor formation. In the April issue of Nature Medicine, Rognoni and colleagues generate a transgenic mouse lacking Kindlin-1 in the epidermis to model the key features of KS, and show that Kindlin-1 regulates Wnt and TGF? signaling independent of ?-integrins. These ?1-integrin-independent functions of Kindlin-1 may contribute to the increased SCC risk in KS patients. Twit Text FOAVip Kindler syndrome in mice and men ????Cancer Biol Ther http://www.kidney.de/pget.php?&tw=1&pmid=24919121 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24919121 #FOAvip English Wikipedia <ref>{{Cite pmid|24919121}}</ref> Kindler syndrome in mice and men #MMPMID24919121 Duperret EK; Ridky TW Cancer Biol Ther 2014[Sep]; 15 (9): 1113-6 PMID24919121show ga Kindler syndrome (KS) in humans is a severe skin blistering disease associated with inflammation and increased risk of epidermal squamous cell carcinoma (SCC). This disease is known to be caused by loss-of-function mutations in Kindlin-1, a focal adhesion ?-integrin binding protein. Thus far, it has been unclear what specific signaling events occur in KS keratinocytes to promote tumorigenesis, especially since loss of ?-integrins and focal adhesion complexes has been previously shown to prevent or delay tumor formation. In the April issue of Nature Medicine, Rognoni and colleagues generate a transgenic mouse lacking Kindlin-1 in the epidermis to model the key features of KS, and show that Kindlin-1 regulates Wnt and TGF? signaling independent of ?-integrins. These ?1-integrin-independent functions of Kindlin-1 may contribute to the increased SCC risk in KS patients. äKindler syndrome in mice and men (epmc).pdf DeepDyve Pubget Overpricing