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2017 ; 18
(9
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English Wikipedia
Kinases Involved in Both Autophagy and Mitosis
#MMPMID28858266
Li Z
; Zhang X
Int J Mol Sci
2017[Aug]; 18
(9
): ä PMID28858266
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Both mitosis and autophagy are highly regulated dynamic cellular processes and
involve various phosphorylation events catalysed by kinases, which play vital
roles in almost all physiological and pathological conditions. Mitosis is a key
event during the cell cycle, in which the cell divides into two daughter cells.
Autophagy is a process in which the cell digests its own cellular contents.
Although autophagy regulation has mainly been studied in asynchronous cells,
increasing evidence indicates that autophagy is in fact tightly regulated in
mitosis. Here in this review, we will discuss kinases that were originally
identified to be involved in only one of either mitosis or autophagy, but were
later found to participate in both processes, such as CDKs (cyclin-dependent
kinases), Aurora kinases, PLK-1 (polo-like kinase 1), BUB1 (budding uninhibited
by benzimidazoles 1), MAPKs (mitogen-activated protein kinases), mTORC1
(mechanistic target of rapamycin complex 1), AMPK (AMP-activated protein kinase),
PI3K (phosphoinositide-3 kinase) and protein kinase B (AKT). By focusing on
kinases involved in both autophagy and mitosis, we will get a more comprehensive
understanding about the reciprocal regulation between the two key cellular
events, which will also shed light on their related therapeutic investigations.
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