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10.1111/jcmm.12749 http://scihub22266oqcxt.onion/10.1111/jcmm.12749 C4759477!4759477 !26648178     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26648178 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26648178 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Cell+Mol+Med 2016 ; 20 (3 ): 389-402 Nephropedia Template TP {{tp|p=26648178 |t=2016. Killing cancer with platycodin D through multiple mechanisms |pdf=|usr=}}{{26648178 }} gab.com Text Killing cancer with platycodin D through multiple mechanisms JO: J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=26648178 #FOAvip Cancer is a multi-faceted disease comprised of a combination of genetic, epigenetic, metabolic and signalling aberrations which severely disrupt the normal homoeostasis of cell growth and death. Rational developments of highly selective drugs which specifically block only one of the signalling pathways have been associated with limited therapeutic success. Multi-targeted prevention of cancer has emerged as a new paradigm for effective anti-cancer treatment. Platycodin D, a triterpenoid saponin, is one the major active components of the roots of Platycodon grandiflorum and possesses multiple biological and pharmacological properties including, anti-nociceptive, anti-atherosclerosis, antiviral, anti-inflammatory, anti-obesity, immunoregulatory, hepatoprotective and anti-tumour activities. Recently, the anti-cancer activity of platycodin D has been extensively studied. The purpose of this review was to give our perspectives on the current status of platycodin D and discuss its anti-cancer activity and molecular mechanisms which may help the further design and conduct of pre-clinical and clinical trials to develop it successfully into a potential lead drug for oncological therapy. Platycodin D has been shown to fight cancer by inducing apoptosis, cell cycle arrest, and autophagy and inhibiting angiogenesis, invasion and metastasis by targeting multiple signalling pathways which are frequently deregulated in cancers suggesting that this multi-target activity rather than a single effect may play an important role in developing platycodin D into potential anti-cancer drug. Twit Text FOAVip Killing cancer with platycodin D through multiple mechanisms ????J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=26648178 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26648178 #FOAvip English Wikipedia <ref>{{Cite pmid|26648178 }}</ref> Killing cancer with platycodin D through multiple mechanisms #MMPMID26648178 Khan M ; Maryam A ; Zhang H ; Mehmood T ; Ma T J Cell Mol Med 2016[Mar]; 20 (3 ): 389-402 PMID26648178 show ga Cancer is a multi-faceted disease comprised of a combination of genetic, epigenetic, metabolic and signalling aberrations which severely disrupt the normal homoeostasis of cell growth and death. Rational developments of highly selective drugs which specifically block only one of the signalling pathways have been associated with limited therapeutic success. Multi-targeted prevention of cancer has emerged as a new paradigm for effective anti-cancer treatment. Platycodin D, a triterpenoid saponin, is one the major active components of the roots of Platycodon grandiflorum and possesses multiple biological and pharmacological properties including, anti-nociceptive, anti-atherosclerosis, antiviral, anti-inflammatory, anti-obesity, immunoregulatory, hepatoprotective and anti-tumour activities. Recently, the anti-cancer activity of platycodin D has been extensively studied. The purpose of this review was to give our perspectives on the current status of platycodin D and discuss its anti-cancer activity and molecular mechanisms which may help the further design and conduct of pre-clinical and clinical trials to develop it successfully into a potential lead drug for oncological therapy. Platycodin D has been shown to fight cancer by inducing apoptosis, cell cycle arrest, and autophagy and inhibiting angiogenesis, invasion and metastasis by targeting multiple signalling pathways which are frequently deregulated in cancers suggesting that this multi-target activity rather than a single effect may play an important role in developing platycodin D into potential anti-cancer drug. |Animals [MESH] |Antineoplastic Agents, Phytogenic/*pharmacology/therapeutic use [MESH] |Cell Survival/drug effects [MESH] |Cell Transformation, Neoplastic/drug effects [MESH] |Drug Screening Assays, Antitumor [MESH] |Drug Synergism [MESH] |Humans [MESH] |Neoplasm Invasiveness [MESH] |Neoplasms/*drug therapy/pathology [MESH] |Neovascularization, Pathologic/drug therapy [MESH] |Saponins/*pharmacology/therapeutic use [MESH]Killing cancer with platycodin D through multiple mechanisms (epmc).pdf DeepDyve Pubget Overpricing