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10.1038/mt.2015.171 http://scihub22266oqcxt.onion/10.1038/mt.2015.171 C4754547!4754547!26419704     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26419704&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26419704.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Ther 2016 ; 24 (1): 125-34 Nephropedia Template TP {{tp|p=26419704|t=2016. Kidney-specific Sonoporation-mediated Gene Transfer |pdf=|usr=}}{{26419704}} gab.com Text Kidney-specific Sonoporation-mediated Gene Transfer JO: Mol Ther http://www.kidney.de/pget.php?&tw=1&pmid=26419704 #FOAvip Sonoporation can deliver agents to target local organs by systemic administration, while decreasing the associated risk of adverse effects. Sonoporation has been used for a variety of materials and in a variety of organs. Herein, we demonstrated that local sonoporation to the kidney can offer highly efficient transfer of oligonucleotides, which were systemically administrated to the tubular epithelium with high specificity. Ultrasonic wave irradiation to the kidney collapsed the microbubbles and transiently affected the glomerular filtration barrier and increased glomerular permeability. Oligonucleotides were passed through the barrier all at once and were absorbed throughout the tubular epithelium. Tumor necrosis factor alpha (TNF?), which plays a central role in renal ischemia?reperfusion injury, was targeted using small interfering RNA (siRNA) with renal sonoporation in a murine model. The reduction of TNF? expression after single gene transfer significantly inhibited the expression of kidney injury markers, suggesting that systemic administration of siRNA under temporary and local sonoporation could be applicable in the clinical setting of ischemic acute kidney injury. Twit Text FOAVip Kidney-specific Sonoporation-mediated Gene Transfer ????Mol Ther http://www.kidney.de/pget.php?&tw=1&pmid=26419704 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26419704 #FOAvip English Wikipedia <ref>{{Cite pmid|26419704}}</ref> Kidney-specific Sonoporation-mediated Gene Transfer #MMPMID26419704 Ishida R; Kami D; Kusaba T; Kirita Y; Kishida T; Mazda O; Adachi T; Gojo S Mol Ther 2016[Feb]; 24 (1): 125-34 PMID26419704show ga Sonoporation can deliver agents to target local organs by systemic administration, while decreasing the associated risk of adverse effects. Sonoporation has been used for a variety of materials and in a variety of organs. Herein, we demonstrated that local sonoporation to the kidney can offer highly efficient transfer of oligonucleotides, which were systemically administrated to the tubular epithelium with high specificity. Ultrasonic wave irradiation to the kidney collapsed the microbubbles and transiently affected the glomerular filtration barrier and increased glomerular permeability. Oligonucleotides were passed through the barrier all at once and were absorbed throughout the tubular epithelium. Tumor necrosis factor alpha (TNF?), which plays a central role in renal ischemia?reperfusion injury, was targeted using small interfering RNA (siRNA) with renal sonoporation in a murine model. The reduction of TNF? expression after single gene transfer significantly inhibited the expression of kidney injury markers, suggesting that systemic administration of siRNA under temporary and local sonoporation could be applicable in the clinical setting of ischemic acute kidney injury. äKidney-specific Sonoporation-mediated Gene Transfer (epmc).pdf DeepDyve Pubget Overpricing