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2018 ; 7
(4
): 317-324
Nephropedia Template TP
Stem Cells Transl Med
2018[Apr]; 7
(4
): 317-324
PMID29575816
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Kidney-derived c-Kit(+) cells exhibit progenitor/stem cell properties in vitro
(self-renewal capacity, clonogenicity, and multipotentiality). These cells can
regenerate epithelial tubular cells following ischemia-reperfusion injury and
accelerate foot processes effacement reversal in a model of acute proteinuria in
rats. Several mechanisms are involved in kidney regeneration by kidney-derived
c-Kit(+) cells, including cell engraftment and differentiation into renal-like
structures, such as tubules, vessels, and podocytes. Moreover, paracrine
mechanisms could also account for kidney regeneration, either by stimulating
proliferation of surviving cells or modulating autophagy and podocyte
cytoskeleton rearrangement through mTOR-Raptor and -Rictor signaling, which
ultimately lead to morphological and functional improvement. To gain insights
into the functional properties of c-Kit(+) cells during kidney development,
homeostasis, and disease, studies on lineage tracing using transgenic mice will
unveil their fate. The results obtained from these studies will set the basis for
establishing further investigation on the therapeutic potential of c-Kit(+) cells
for treatment of kidney disease in preclinical and clinical studies. Stem Cells
Translational Medicine 2018;7:317-324.
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