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2016 ; 9
(3
): 403-7
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Kidney transplant outcomes in familial C3 glomerulopathy
#MMPMID27274824
Wong L
; Moran S
; Lavin PJ
; Dorman AM
; Conlon PJ
Clin Kidney J
2016[Jun]; 9
(3
): 403-7
PMID27274824
show ga
C3 glomerulopathy, a newly designated entity, is characterized by glomerular
disease associated with dysregulation of the alternative complement pathway and
is a rare cause of end-stage kidney disease. Overall disease characteristics that
include clinical presentation, laboratory assessment, histopathology and genetic
background have only been unravelled in recent years and have led to the
development of anti-complement therapies targeting different levels of the
alternative pathway. We describe the long-term outcomes following kidney
transplantation in an Irish family with familial C3 glomerulopathy due to a
hybrid CFHR3-1 gene.