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2015 ; 3
(1
): 67-79
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Kidney Regeneration: Lessons from Development
#MMPMID26120499
Chiba T
; Hukriede N
; de Caestecker MP
Curr Pathobiol Rep
2015[Mar]; 3
(1
): 67-79
PMID26120499
show ga
A number of genes involved in kidney development are reactivated in the adult
after acute kidney injury (AKI). This has led to the belief that tissue repair
mechanisms recapitulate pathways involved in embryonic development after AKI. We
will discuss evidence to support this hypothesis by comparing the mechanisms of
development with common pathways known to regulate post-AKI repair, or that we
identified as cell-specific candidates based on public datasets from recent AKI
translational profiling studies. We will argue that while many of these
developmental pathways are reactivated after AKI, this is not associated with
general cellular reprogramming to an embryonic state. We will show that
reactivation of these developmental genes is often associated with expression in
cells that are not normally involved in mediating parallel responses in the
embryo, and that depending on the cellular context, these responses can have
beneficial or detrimental effects on injury and repair after AKI.
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