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10.1194/jlr.R046292 http://scihub22266oqcxt.onion/10.1194/jlr.R046292 C4173993!4173993 !24714648     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24714648 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Lipid+Res 2014 ; 55 (10 ): 2004-6 Nephropedia Template TP {{tp|p=24714648 |t=2014. Ketone ester effects on metabolism and transcription |pdf=|usr=}}{{24714648 }} gab.com Text Ketone ester effects on metabolism and transcription JO: J Lipid Res http://www.kidney.de/pget.php?&tw=1&pmid=24714648 #FOAvip Ketosis induced by starvation or feeding a ketogenic diet has widespread and often contradictory effects due to the simultaneous elevation of both ketone bodies and free fatty acids. The elevation of ketone bodies increases the energy of ATP hydrolysis by reducing the mitochondrial NAD couple and oxidizing the coenzyme Q couple, thus increasing the redox span between site I and site II. In contrast, metabolism of fatty acids leads to a reduction of both mitochondrial NAD and mitochondrial coenzyme Q causing a decrease in the ?G of ATP hydrolysis. In contrast, feeding ketone body esters leads to pure ketosis, unaccompanied by elevation of free fatty acids, producing a physiological state not previously seen in nature. The effects of pure ketosis on transcription and upon certain neurodegenerative diseases make approach not only interesting, but of potential therapeutic value. Twit Text FOAVip Ketone ester effects on metabolism and transcription ????J Lipid Res http://www.kidney.de/pget.php?&tw=1&pmid=24714648 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24714648 #FOAvip English Wikipedia <ref>{{Cite pmid|24714648 }}</ref> Ketone ester effects on metabolism and transcription #MMPMID24714648 Veech RL J Lipid Res 2014[Oct]; 55 (10 ): 2004-6 PMID24714648 show ga Ketosis induced by starvation or feeding a ketogenic diet has widespread and often contradictory effects due to the simultaneous elevation of both ketone bodies and free fatty acids. The elevation of ketone bodies increases the energy of ATP hydrolysis by reducing the mitochondrial NAD couple and oxidizing the coenzyme Q couple, thus increasing the redox span between site I and site II. In contrast, metabolism of fatty acids leads to a reduction of both mitochondrial NAD and mitochondrial coenzyme Q causing a decrease in the ?G of ATP hydrolysis. In contrast, feeding ketone body esters leads to pure ketosis, unaccompanied by elevation of free fatty acids, producing a physiological state not previously seen in nature. The effects of pure ketosis on transcription and upon certain neurodegenerative diseases make approach not only interesting, but of potential therapeutic value. |Adenosine Triphosphate/metabolism [MESH] |Diet, Ketogenic/adverse effects [MESH] |Esters [MESH] |Fatty Acids/*metabolism [MESH] |Humans [MESH] |Ketones/*metabolism [MESH] |Ketosis/*metabolism/pathology [MESH] |NAD/metabolism [MESH] |Starvation/metabolism/pathology [MESH]Ketone ester effects on metabolism and transcription (epmc).pdf DeepDyve Pubget Overpricing