Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27590181
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Expert+Rev+Clin+Immunol
2017 ; 13
(3
): 247-258
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Kawasaki disease: etiopathogenesis and novel treatment strategies
#MMPMID27590181
Agarwal S
; Agrawal DK
Expert Rev Clin Immunol
2017[Mar]; 13
(3
): 247-258
PMID27590181
show ga
Kawasaki disease is an acute febrile systemic vasculitis that predominantly
occurs in children below five years of age. Its etiopathogenesis is still not
clear, but it is thought to be a complex interplay of genetic factors, infections
and immunity. Areas covered: This review article discusses in detail Kawasaki
disease, with particular emphasis on the recent updates on its pathogenesis and
upcoming alternate treatment options. Though self-limiting in many cases, it can
lead to severe complications like coronary artery aneurysms and thrombo-embolic
occlusions, and hence requires early diagnosis and urgent attention to avoid
them. Intravenous immunoglobulin (IVIG) with or without aspirin has remained the
sole treatment option for these cases, but 10-15% cases develop resistance to
this treatment. Expert commentary: There is a need to develop additional
treatment strategies for children with Kawasaki disease. Targeting different
steps of pathogenesis could provide us with alternate therapeutic options.
|Animals
[MESH]
|Aspirin/*therapeutic use
[MESH]
|Child, Preschool
[MESH]
|Drug Resistance
[MESH]
|Early Diagnosis
[MESH]
|Gene-Environment Interaction
[MESH]
|Humans
[MESH]
|Immunoglobulins, Intravenous/*therapeutic use
[MESH]