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2014 ; 123
(3
): 169-81
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KNL1: bringing order to the kinetochore
#MMPMID24310619
Caldas GV
; DeLuca JG
Chromosoma
2014[Jun]; 123
(3
): 169-81
PMID24310619
show ga
KNL1 is an evolutionarily conserved kinetochore-associated protein essential for
accurate chromosome segregation in eukaryotic cells. This large scaffold protein,
predicted to be almost entirely unstructured, is involved in diverse mitotic
processes including kinetochore assembly, chromosome congression, and mitotic
checkpoint signaling. How this kinetochore "hub" coordinates protein-protein
interactions spatially and temporally during mitosis to orchestrate these
processes is an area of active investigation. Here we summarize the current
understanding of KNL1 and discuss possible mechanisms by which this protein
actively contributes to multiple aspects of mitotic progression.