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2017 ; 8
(ä): 403
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Jumbo Bacteriophages: An Overview
#MMPMID28352259
Yuan Y
; Gao M
Front Microbiol
2017[]; 8
(ä): 403
PMID28352259
show ga
Tailed bacteriophages with genomes larger than 200 kbp are classified as Jumbo
phages, and are rarely isolated by conventional methods. These phages are
designated "jumbo" owing to their most notable features of a large phage virion
and large genome size. However, in addition to these, jumbo phages also exhibit
several novel characteristics that have not been observed for phages with smaller
genomes, which differentiate jumbo phages in terms of genome organization, virion
structure, progeny propagation, and evolution. In this review, we summarize
available reports on jumbo phages and discuss the differences between jumbo
phages and small-genome phages. We also discuss data suggesting that jumbo phages
might have evolved from phages with smaller genomes by acquiring additional
functional genes, and that these additional genes reduce the dependence of the
jumbo phages on the host bacteria.