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2017 ; 50
(48
): 483001
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Jamming transitions in cancer
#MMPMID29628530
Oswald L
; Grosser S
; Smith DM
; Käs JA
J Phys D Appl Phys
2017[Oct]; 50
(48
): 483001
PMID29628530
show ga
The traditional picture of tissues, where they are treated as liquids defined by
properties such as surface tension or viscosity has been redefined during the
last few decades by the more fundamental question: under which conditions do
tissues display liquid-like or solid-like behaviour? As a result, basic concepts
arising from the treatment of tissues as solid matter, such as cellular jamming
and glassy tissues, have shifted into the current focus of biophysical research.
Here, we review recent works examining the phase states of tissue with an
emphasis on jamming transitions in cancer. When metastasis occurs, cells gain the
ability to leave the primary tumour and infiltrate other parts of the body.
Recent studies have shown that a linkage between an unjamming transition and
tumour progression indeed exists, which could be of importance when designing
surgery and treatment approaches for cancer patients.