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10.5483/bmbrep.2015.48.5.021 http://scihub22266oqcxt.onion/10.5483/bmbrep.2015.48.5.021 C4578565!4578565 !25787993     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25787993 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       BMB+Rep 2015 ; 48 (5 ): 266-70 Nephropedia Template TP {{tp|p=25787993 |t=2015. Isocitrate dehydrogenase mutations: new opportunities for translational research |pdf=|usr=}}{{25787993 }} gab.com Text Isocitrate dehydrogenase mutations: new opportunities for translational research JO: BMB Rep http://www.kidney.de/pget.php?&tw=1&pmid=25787993 #FOAvip Over the last decade, comprehensive genome-wide sequencing studies have enabled us to find out unexpected genetic alterations of metabolism in cancer. An example is the identification of arginine missense mutations of isocitrate dehydrogenases-1 and -2 (IDH1/2) in glioma, acute myeloid leukemia (AML), chondrosarcomas, and cholangiocarcinoma. These alterations are closely associated with the production of a new stereospecific metabolite, (R)-2-hydroxyglutarate (R-2HG). A large number of follow-up studies have been performed to address the molecular mechanisms of IDH1/2 mutations underlying how these events contribute to malignant transformation. In the meanwhile, the development of selective mutant IDH1/2 chemical inhibitors is being actively pursued in the scientific community and pharmaceutical industry. The present review article briefly discusses the important findings that highlight the molecular mechanisms of IDH1/2 mutations in cancer and provides a current status for development of selective mutant IDH1/2 chemical inhibitors. Twit Text FOAVip Isocitrate dehydrogenase mutations: new opportunities for translational research ????BMB Rep http://www.kidney.de/pget.php?&tw=1&pmid=25787993 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25787993 #FOAvip English Wikipedia <ref>{{Cite pmid|25787993 }}</ref> Isocitrate dehydrogenase mutations: new opportunities for translational research #MMPMID25787993 Keum YS ; Choi BY BMB Rep 2015[May]; 48 (5 ): 266-70 PMID25787993 show ga Over the last decade, comprehensive genome-wide sequencing studies have enabled us to find out unexpected genetic alterations of metabolism in cancer. An example is the identification of arginine missense mutations of isocitrate dehydrogenases-1 and -2 (IDH1/2) in glioma, acute myeloid leukemia (AML), chondrosarcomas, and cholangiocarcinoma. These alterations are closely associated with the production of a new stereospecific metabolite, (R)-2-hydroxyglutarate (R-2HG). A large number of follow-up studies have been performed to address the molecular mechanisms of IDH1/2 mutations underlying how these events contribute to malignant transformation. In the meanwhile, the development of selective mutant IDH1/2 chemical inhibitors is being actively pursued in the scientific community and pharmaceutical industry. The present review article briefly discusses the important findings that highlight the molecular mechanisms of IDH1/2 mutations in cancer and provides a current status for development of selective mutant IDH1/2 chemical inhibitors. |*Mutation, Missense [MESH] |*Translational Research, Biomedical [MESH] |Arginine/genetics [MESH] |Enzyme Inhibitors/pharmacology [MESH] |Glutarates/metabolism [MESH] |Humans [MESH] |Isocitrate Dehydrogenase/antagonists & inhibitors/*genetics [MESH] |Isoenzymes/*genetics [MESH]Isocitrate dehydrogenase mutations: new opportunities for translationa(epmc).pdf DeepDyve Pubget Overpricing