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2016 ; 9
(ä): 2437-46
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Irreversible electroporation: state of the art
#MMPMID27217767
Wagstaff PG
; Buijs M
; van den Bos W
; de Bruin DM
; Zondervan PJ
; de la Rosette JJ
; Laguna Pes MP
Onco Targets Ther
2016[]; 9
(ä): 2437-46
PMID27217767
show ga
The field of focal ablative therapy for the treatment of cancer is characterized
by abundance of thermal ablative techniques that provide a minimally invasive
treatment option in selected tumors. However, the unselective destruction
inflicted by thermal ablation modalities can result in damage to vital structures
in the vicinity of the tumor. Furthermore, the efficacy of thermal ablation
intensity can be impaired due to thermal sink caused by large blood vessels in
the proximity of the tumor. Irreversible electroporation (IRE) is a novel
ablation modality based on the principle of electroporation or
electropermeabilization, in which electric pulses are used to create nanoscale
defects in the cell membrane. In theory, IRE has the potential of overcoming the
aforementioned limitations of thermal ablation techniques. This review provides a
description of the principle of IRE, combined with an overview of in vivo
research performed to date in the liver, pancreas, kidney, and prostate.