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2015 ; 7
(12
): 1541-54
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Iron and zinc exploitation during bacterial pathogenesis
#MMPMID26497057
Ma L
; Terwilliger A
; Maresso AW
Metallomics
2015[Dec]; 7
(12
): 1541-54
PMID26497057
show ga
Ancient bacteria originated from metal-rich environments. Billions of years of
evolution directed these tiny single cell creatures to exploit the versatile
properties of metals in catalyzing chemical reactions and biological responses.
The result is an entire metallome of proteins that use metal co-factors to
facilitate key cellular process that range from the production of energy to the
replication of DNA. Two key metals in this regard are iron and zinc, both
abundant on Earth but not readily accessible in a human host. Instead, pathogenic
bacteria must employ clever ways to acquire these metals. In this review we
describe the many elegant ways these bacteria mine, regulate, and craft the use
of two key metals (iron and zinc) to build a virulence arsenal that challenges
even the most sophisticated immune response.