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2015 ; 29
(2
): 183-90
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Ipsilesional neglect: behavioral and anatomical correlates
#MMPMID25180980
Sacchetti DL
; Goedert KM
; Foundas AL
; Barrett AM
Neuropsychology
2015[Mar]; 29
(2
): 183-90
PMID25180980
show ga
[Correction Notice: An Erratum for this article was reported in Vol 29(2) of
Neuropsychology (see record 2014-42242-001). The funding source information was
missing from the author note, and A. M. Barrett's institutional affiliation was
incorrect. The funding source information and Barrett's correct institutional
affiliation are provided in the erratum.] OBJECTIVE: The sparse existing research
on ipsilesional neglect supports an association of this disorder with damage to
the right frontal and subcortical brain networks. It is believed that dysfunction
in these networks may result in primarily "aiming" motor-intentional spatial
errors. The purpose of this study was to confirm whether frontal-subcortical
circuits are indeed commonly affected in ipsilesional neglect and to determine
the relative presence of "aiming" motor-intentional versus "where"
perceptual-attentional spatial errors in these individuals. METHODS: We
identified 12 participants with ipsilesional neglect based on a computerized line
bisection task and used the line bisection data to quantify participants'
perceptual-attentional and motor-intentional errors. We were able to discriminate
between these 2 biases using the algebraic solutions for 2 separate equations,
one for "aiming" and one for "where" biases. Lesion mapping was conducted for all
participants using MRIcron software; lesion checklist and overlap analysis were
created from these images. RESULTS: A greater percentage of participants with
ipsilesional neglect had frontal/subcortical damage (83%) compared with the
expected percentage (27%) observed in published patient samples with
contralesional neglect. We observed the greatest area of lesion overlap in
frontal lobe white matter pathways. Nevertheless, participants with ipsilesional
neglect made primarily "where" rather than "aiming" spatial errors. CONCLUSION:
Our data confirm previous research suggesting that ipsilesional neglect may
result from lesions to the right frontal-subcortical networks. Furthermore, in
our group, ipsilesional neglect was also strongly associated with primarily
"where" perceptual-attentional bias, and less so with "aiming" motor-intentional
spatial bias.
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