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2014 ; 21
(2
): 218-20
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Ionizing radiation: mechanisms and therapeutics
#MMPMID24702164
Furdui CM
Antioxid Redox Signal
2014[Jul]; 21
(2
): 218-20
PMID24702164
show ga
While chemotherapy and radiation therapy have been integral components of cancer
management for decades, the issues of local recurrence, clinical resistance, and
toxicities resulting from these treatment modalities have increased the interest
in novel therapeutic approaches that could attenuate tumor progression and
prevent recurrences. This Forum highlights current research focused on
elucidation of the mechanisms of response to radiation treatment and the
development of out-of-the-box therapeutic strategies for cancer treatment with
radiation. Experts in the field of radiation research contribute with review
articles describing the current knowledge on DNA damage response mechanisms,
regulation of signaling involved in the DNA damage response by miRNA, the
function of tumor hypoxia in tumor response to radiation, and the role of stem
cells in protection of normal tissue against radiation damage.
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