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10.1007/s00399-017-0542-y http://scihub22266oqcxt.onion/10.1007/s00399-017-0542-y C5846830!5846830 !29214349     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29214349 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Herzschrittmacherther+Elektrophysiol 2018 ; 29 (1 ): 30-35 Nephropedia Template TP {{tp|p=29214349 |t=2018. Ionenkanäle als Teil makromolekularer Multiproteinkomplexe : Klinische Signifikanz |pdf=|usr=}}{{29214349 }} gab.com Text Ionenkanäle als Teil makromolekularer Multiproteinkomplexe : Klinische Signifikanz JO: Herzschrittmacherther Elektrophysiol http://www.kidney.de/pget.php?&tw=1&pmid=29214349 #FOAvip Ion channels and Ca(2+)-handling proteins involved in the regulation of cardiac electrophysiology and contractility are organized in macromolecular multiprotein complexes. Recent molecular and cellular studies have significantly enhanced our understanding of the composition of these macromolecular complexes and have helped to elucidate their role in the dynamic regulation of ion channel function. Moreover, it has become clear that alterations in the composition of ion channel macromolecular complexes, for example, due to genetic mutations or acquired alterations in the expression of individual components, may lead to ion channel dysfunction and arrhythmogenesis. Here, we review novel insights into the composition of the major ion channel macromolecular complexes and discuss the potential clinical significance of alterations in these dynamic multiprotein structures. Twit Text FOAVip Ionenkanäle als Teil makromolekularer Multiproteinkomplexe : Klinische Signifikanz ????Herzschrittmacherther Elektrophysiol http://www.kidney.de/pget.php?&tw=1&pmid=29214349 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29214349 #FOAvip English Wikipedia <ref>{{Cite pmid|29214349 }}</ref> Ionenkanäle als Teil makromolekularer Multiproteinkomplexe : Klinische Signifikanz #MMPMID29214349 Heijman J ; Dobrev D Herzschrittmacherther Elektrophysiol 2018[Mar]; 29 (1 ): 30-35 PMID29214349 show ga Ion channels and Ca(2+)-handling proteins involved in the regulation of cardiac electrophysiology and contractility are organized in macromolecular multiprotein complexes. Recent molecular and cellular studies have significantly enhanced our understanding of the composition of these macromolecular complexes and have helped to elucidate their role in the dynamic regulation of ion channel function. Moreover, it has become clear that alterations in the composition of ion channel macromolecular complexes, for example, due to genetic mutations or acquired alterations in the expression of individual components, may lead to ion channel dysfunction and arrhythmogenesis. Here, we review novel insights into the composition of the major ion channel macromolecular complexes and discuss the potential clinical significance of alterations in these dynamic multiprotein structures. |Animals [MESH] |Arrhythmias, Cardiac/genetics/*physiopathology [MESH] |Calcium Channels/genetics/*physiology [MESH] |DNA Mutational Analysis [MESH] |Humans [MESH] |Ion Channels/genetics/*physiology [MESH] |Macromolecular Substances/*metabolism [MESH] |Multiprotein Complexes/genetics/*physiology [MESH]Ionenkanäle als Teil makromolekularer Multiproteinkomplexe : Klinische(epmc).pdf DeepDyve Pubget Overpricing