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10.1146/annurev-immunol-032414-112212 http://scihub22266oqcxt.onion/10.1146/annurev-immunol-032414-112212 C4822408!4822408!25861976     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25861976&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25861976.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Annu+Rev+Immunol 2015 ; 33 (ä): 291-353 Nephropedia Template TP {{tp|p=25861976|t=2015. Ion Channels in Innate and Adaptive Immunity |pdf=|usr=}}{{25861976}} gab.com Text Ion Channels in Innate and Adaptive Immunity JO: Annu Rev Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25861976 #FOAvip Ion channels and transporters mediate the transport of charged ions across hydrophobic lipid membranes. In immune cells, divalent cations such as calcium, magnesium, and zinc have important roles as second messengers to regulate intracellular signaling pathways. By contrast, monovalent cations such as sodium and potassium mainly regulate the membrane potential, which indirectly controls the influx of calcium and immune cell signaling. Studies investigating human patients with mutations in ion channels and transporters, analysis of gene-targeted mice, or pharmacological experiments with ion channel inhibitors have revealed important roles of ionic signals in lymphocyte development and in innate and adaptive immune responses. We here review the mechanisms underlying the function of ion channels and transporters in lymphocytes and innate immune cells and discuss their roles in lymphocyte development, adaptive and innate immune responses, and autoimmunity, as well as recent efforts to develop pharmacological inhibitors of ion channels for immunomodulatory therapy. Twit Text FOAVip Ion Channels in Innate and Adaptive Immunity ????Annu Rev Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25861976 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25861976 #FOAvip English Wikipedia <ref>{{Cite pmid|25861976}}</ref> Ion Channels in Innate and Adaptive Immunity #MMPMID25861976 Feske S; Wulff H; Skolnik EY Annu Rev Immunol 2015[]; 33 (ä): 291-353 PMID25861976show ga Ion channels and transporters mediate the transport of charged ions across hydrophobic lipid membranes. In immune cells, divalent cations such as calcium, magnesium, and zinc have important roles as second messengers to regulate intracellular signaling pathways. By contrast, monovalent cations such as sodium and potassium mainly regulate the membrane potential, which indirectly controls the influx of calcium and immune cell signaling. Studies investigating human patients with mutations in ion channels and transporters, analysis of gene-targeted mice, or pharmacological experiments with ion channel inhibitors have revealed important roles of ionic signals in lymphocyte development and in innate and adaptive immune responses. We here review the mechanisms underlying the function of ion channels and transporters in lymphocytes and innate immune cells and discuss their roles in lymphocyte development, adaptive and innate immune responses, and autoimmunity, as well as recent efforts to develop pharmacological inhibitors of ion channels for immunomodulatory therapy. äIon Channels in Innate and Adaptive Immunity (epmc).pdf DeepDyve Pubget Overpricing