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2014 ; 93
(10-12
): 367-79
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Invadosomes in their natural habitat
#MMPMID25457677
Génot E
; Gligorijevic B
Eur J Cell Biol
2014[Oct]; 93
(10-12
): 367-79
PMID25457677
show ga
Podosomes and invadopodia (collectively known as invadosomes) are small,
F-actin-rich protrusions that are located at points of cell-ECM contacts and
endow cells with invasive capabilities. So far, they have been identified in
human or murine immune (myelomonocytic), vascular and cancer cells. The
overarching reason for studying invadosomes is their connection to human disease.
For example, macrophages and osteoclasts lacking Wiskott-Aldrich syndrome protein
(WASp) are not able to form podosomes, and this leads to altered macrophage
chemotaxis and defective bone resorption by osteoclasts. In contrast, the ability
of cancer cells to form invadopodia is associated with high invasive and
metastatic potentials. While invadosome composition, dynamics and signaling
cascades leading to their assembly can be followed easily in in vitro assays,
studying their contribution to pathophysiological processes in situ remains
challenging. A number of recent papers have started to address this issue and
describe invadosomes in situ in mouse models of cancer, cardiovascular disease
and angiogenesis. In addition, in vivo invadosome homologs have been reported in
developmental model systems such as C. elegans, zebrafish and sea squirt.
Comparative analyses among different invasion mechanisms as they happen in their
natural habitats, i.e., in situ, may provide an outline of the invadosome
evolutionary history, and guide our understanding of the roles of the invasion
process in pathophysiology versus development.
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