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2014 ; 8
(3
): 246-55
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Invadopodia and basement membrane invasion in vivo
#MMPMID24717190
Lohmer LL
; Kelley LC
; Hagedorn EJ
; Sherwood DR
Cell Adh Migr
2014[]; 8
(3
): 246-55
PMID24717190
show ga
Over 20 years ago, protrusive, F-actin-based membrane structures, termed
invadopodia, were identified in highly metastatic cancer cell lines. Invadopodia
penetrate artificial or explanted extracellular matrices in 2D culture conditions
and have been hypothesized to facilitate the migration of cancer cells through
basement membrane, a thin, dense, barrier-like matrix surrounding most tissues.
Despite intensive study, the identification of invadopodia in vivo has remained
elusive and until now their possible roles during invasion or even existence have
remained unclear. Studies in remarkably different cellular contexts-mouse tumor
models, zebrafish intestinal epithelia, and C. elegans organogenesis-have
recently identified invadopodia structures associated with basement membrane
invasion. These studies are providing the first in vivo insight into the
regulation, function, and role of these fascinating subcellular devices with
critical importance to both development and human disease.