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2017 ; 9
(ä): 38
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Introducing the sporobiota and sporobiome
#MMPMID28680484
Tetz G
; Tetz V
Gut Pathog
2017[]; 9
(ä): 38
PMID28680484
show ga
Unrelated spore-forming bacteria share unique characteristics stemming from the
presence of highly resistant endospores, leading to similar challenges in health
and disease. These characteristics are related to the presence of these highly
transmissible spores, which are commonly spread within the environment and are
implicated in host-to-host transmission. In humans, spore-forming bacteria
contribute to a variety of pathological processes that share similar
characteristics, including persistence, chronicity, relapses and the maintenance
of the resistome. We first outline the necessity of characterizing the totality
of the spore-forming bacteria as the sporobiota based on their unique common
characteristics. We further propose that the collection of all genes of
spore-forming bacteria be known as the sporobiome. Such differentiation is
critical for exploring the cross-talk between the sporobiota and other members of
the gut microbiota, and will allow for a better understanding of the implications
of the sporobiota and sporobiome in a variety of pathologies and the spread of
antibiotic resistance.